High-dose baclofen for the treatment of alcohol dependence (BACLAD study): A randomized, placebo-controlled trial.
Müller C.A, Geisel O., Pelz P. et al.
European Neuropsychopharmacology: 2015, 25, p. 1167–1177.
From Germany the first trial to rigorously test high doses of the muscle relaxant baclofen for the treatment of dependent drinking found post-detoxification drinking reductions of a magnitude rarely seen; safety issues remain, but it seems these can be managed with close monitoring and individualised dosing.
Summary In the USA and Europe few medications have been approved for the treatment of dependent drinking: disulfiram, acamprosate, nalmefene, and naltrexone oral and injectable. Some have repeatedly been found effective in rigorous clinical trials, but effects have been modest – there is room for improvement through additions to this range.
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