Gamma-HydroxyButyrate (GHB)- deficiency in alcohol-dependence – 2007

Olivier Ameisen – Alcohol & Alcoholism Vol. 42, No. 5, p. 506, 2007

I wish to propose a hypothesis that could help explain some of the effects of baclofen in alcohol dependence that are described in Dr. Bucknam’s case study (Bucknam, 2007) and in my self-case report (Ameisen, 2005). At a behavioural level, alcohol, baclofen and GHB all share sedative/hypnotic effects in humans. Clinical trials have shown baclofen to reduce anxiety in alcoholic (Krupitsky et al ., 1993; Addolorato et al ., 2002) and non-alcoholic (Breslow et al ., 1989; Drake et al ., 2003) patients alike.

GHB deficiency in alcohol dependance

Déficience en GHB dans l’alcoolo-dépendance

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